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We help founders who

harness biology to

engineer better products

.

Investing in technology for people & planet

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create scalable solutions to

climate change

.

Investing in technology for people & planet

We help founders who

deploy AI & automation to

empower us

.

Investing in technology for people & planet

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We help founders who

deliver healthcare that's

personal & proactive

.

Investing in technology for people & planet

Because they are cool

and helpful

We help founders who

transport us safely, with

zero carbon footprint

.

Investing in technology for people & planet

Because they are cool

and helpful

Our Purpose.

We invest capital, time & belief to accelerate your success.

Every startup journey is unique - there's no single playbook that works for everyone, especially in the early days. We try to meet you where you are and help you get where you dream of going. We listen with empathy, we tell you the truth and we'll dive in to contribute hands-on support whenever you need it. You should expect nothing less from any investor.

We invest in driven founders who can build pioneering companies that improve our world.

Our Focus

We partner closely with our founders from the beginning, and we're on call when they need us most.

Our Approach

Harsh was the first VC we met who immediately understood our potential, and he's been a trusted mentor to me since our seed round. His empathy & experience building companies in our space make him an ideal investor for any 1st-time founder."

Trevor Martin

Co-founder & CEO, Mammoth Biosciences

Wireframe led our seed round and they’ve been invaluable to me as a solo founder. I’ve been able to rely on Paul as a true partner. We have an open, trusted relationship that goes well beyond what most founders might expect from their investors."

Arch Rao

Founder & CEO, SPAN

Wireframe’s expertise in the EV & energy markets made them the perfect lead VC for our seed round. Paul & Harsh are great partners, striking the right balance between strategic guidance & support while giving us flexibility to execute our vision."

Muffi Ghadiali

Founder & CEO, Electriphi

Before we ever raised capital, Harsh introduced us to our lead scientific advisor & spent hours with us on a whiteboard helping to hone our thinking. The Wireframe team were great partners at GeneWEAVE and we're excited to work with them again."

Diego Rey

Co-founder & CSO, Endpoint Health

Harsh is a great partner, in both good & tough times. He’s always available to help and pushes us to a high standard. And we'll forever appreciate his clarity & conviction to go all-in on Airflow, a decision that changed the course of our company."

Ry Walker

Founder, Astronomer

Wireframe's value to MycoWorks far exceeds the size of their check. This is the second time I've worked with Paul. He's always available, responsive and thoughtful. I trust his input and contribution as a true partner in building my business."

Matt Scullin

CEO, Mycoworks

Harsh brings a lifetime of wisdom coupled with uncanny insight, empathy, and authentic conviction to his investments. He is single-handedly the 'accelerator' you wished existed. He'll be the first person I call when I start my next company."

Viswa Colluru

Founder & CEO, Enveda Biosciences

Paul led our seed round and has been with me for the 7+ years since, through all of the highs and lows. There's no better partner I can imagine. Many investors say they are founder first - Paul's the real deal."

Andy Ruben

Founder & CEO, Trove

Wireframe was among the first funds to believe in us, and Paul and Harsh have been the most reliable, empathetic partners ever since. Whether supporting & advising us day-to-day or navigating a global crisis, I knew I could always lean on them."

Rema Matevosyan

Co-founder & CEO, Near Space Labs

I've worked with Harsh over 13 years as an investor in 2 of my companies. I’ve relied on his honesty and perspective on company-building time & time again. Having met hundreds of investors, he is easily in my top 5 of all time."

Tim Enwall

CEO, Misty Robotics

Our Portfolio.

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Our founders are on a mission to build a better future.

Product.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

People.

Purpose.

Product.

People.

Product.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

Product.

People.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

Product.

People.

Bioscience

The next generation of CRISPR, built to deliver permanent cures

Mammoth Biosciences

Seed

—

January 2018

Ultracompact CRISPR systems, delivered in vivo, to create permanent cures for serious disease

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Energy

Building the world's most powerful lasers for national defense and clean fusion energy

Xcimer Energy

Seed

—

October 2022

The world’s first superlaser company, building the highest-energy lasers for fusion power and national defense

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Energy

XFRA turns the unused power in every home into a distributed AI data center

SPAN

Seed

—

December 2018

Smart electrical panels that control every circuit in the home, and unlock excess power to run distributed AI compute

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Computing

AI computing systems built on superconductors and light

Great Sky

Seed

—

September 2025

Next-generation AI systems that compute with superconductors & communicate with light

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Enterprise

Empowering organizations to solve their most challenging problems

Palantir

Series A

—

October 2005

Empowering organizations to deploy data and AI to solve their most complex and mission-critical problems (Nasdaq: PLTR)

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Bioscience

AI-enabled discovery of differentiated medicines, at record pace

Enveda

Pre-seed

—

September 2019

Developing blockbuster drugs using AI trained on billions of years of evolutionary intelligence

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Energy

Where the world's biggest energy buyers and sellers get clean energy deals done

LevelTen Energy

Series A

—

September 2017

The marketplace where utility-scale clean energy is bought and sold

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Energy

Maximize the profitability of energy storage projects

Tyba

Pre-seed

—

October 2022

Mission control for energy storage and generation, from market bidding to dispatch to optimization

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Industrials

Reinventing the electrical conducting materials that power our world

Arcturus

Seed

—

March 2026

Using lasers to infuse metals with carbon nanomaterials, creating the next generation of conductors

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Our Team.

Meet the team

Meet our founders.

Harsh Patel

Co-Founder
Managing Director

Paul Straub

Co-Founder
Managing Director

Committed to your success.

We started Wireframe to serve founders solving some of the world's most important challenges. Over the years as investors & operators, we've built networks and domain expertise across themes we care deeply about. And we've been fortunate to work closely with founders from inception to success. As 1st check investors, we are completely aligned with you from the start.
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Our Community.

Climb together.

We're building a community where founders can share hard-earned lessons with their peers and pay it forward to the next generation when they succeed.

Highlights from our community.

Read about the latest news, interviews, and events happening across our community.

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Sep 23, 2026

—

WSJ

Enveda Biosciences

hits $2 billion valuation as it advances AI-discovered drug candidates into late-stage trials

News

Sep 13, 2026

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TechCrunch

Xcimer

emerges as a bridge between fusion power and national defense

News

Jul 23, 2026

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RuntimeWire