We help founders build

a healthier & more sustainable future.

Wireframe Ventures

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Portfolio
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For our founders
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Read our 2024 Impact Report

We help founders who

deploy AI & automation to

empower us

.

Investing in technology for people & planet

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Our Purpose.

We invest capital, time & belief to accelerate your success.

Every startup journey is unique - there's no single playbook that works for everyone, especially in the early days. We try to meet you where you are and help you get where you dream of going. We listen with empathy, we tell you the truth and we'll dive in to contribute hands-on support whenever you need it. You should expect nothing less from any investor.
We invest in driven founders who can build pioneering companies that improve our world.
Our Focus
We partner closely with our founders from the beginning, and we're on call when they need us most.
Our Approach

Harsh brings a lifetime of wisdom coupled with uncanny insight, empathy, and authentic conviction to his investments. He is single-handedly the 'accelerator' you wished existed. He'll be the first person I call when I start my next company."

Viswa Colluru

Founder & CEO, Enveda Biosciences
"
Our Portfolio.
View all

Our founders are on a mission to build a better future.

Product.
Product.
Purpose.
People.
Product.
Purpose.
People.
People.
People.
People.
People.
Product.
Purpose.
People.
Product.
Purpose.
Product.
Product.
Purpose.
Purpose.
People.
Product.
Purpose.
People.
Product.
Purpose.
Purpose.
Bioscience

Improving human health with new diagnostics & therapeutics built with CRISPR

Mammoth Biosciences

Seed
—
January 2018
Discovering & commercializing novel CRISPR systems that enable new possibilities for expanding biology
View site →
Retail

Powering a new circular economy for the world's best retail brands

Trove

Seed
—
May 2013
Driven by a belief that sustainability is the only way forward for retail, helping brands succeed & the world thrive
View site →
Energy

The new interface for home energy

SPAN.io

Seed
—
December 2018
Making home energy connected & intuitive with a smart electrical panel that makes it easier to adopt clean energy
View site →
Enterprise

Empowering organizations to solve their most challenging problems

Palantir

Series A
—
October 2005
Software empowering organizations with the insights they need to solve complex, mission-critical problems (NYSE: PLTR)
View site →
Agriculture

Solving food waste at the farm level

Full Harvest

Seed
—
October 2016
Optimizing the agricultural supply chain with a business marketplace for imperfect & surplus produce
View site →
Retail

A new class of material, sustainably crafted from nature

Mycoworks

Series A
—
May 2019
Bioengineering a sustainable, high-performance & animal-free alternative to leather using fine mycelium
View site →
Bioscience

Applying AI to engineer next-generation cancer therapies

Reverie Labs

Seed
—
March 2018
Solutions for the most difficult, multi-objective medicinal chemistry problems to fill pressing medical needs
View site →
Financial Services

Believing in the power of values-based investing

OpenInvest

Seed
—
May 2017
Making it simple, and profitable, to align your investments with your values (acq. by JPMorgan, NYSE: JPM)
View site →
Energy

Simplifying renewable energy procurement for any corporation

LevelTen Energy

Series A
—
September 2017
The industry's leading platform for corporate energy buyers to find the right renewable energy solutions
View site →
Our Team.
Meet the team

Meet our founders.

Harsh Patel

  • Co-Founder
  • Managing Director

Paul Straub

  • Co-Founder
  • Managing Director

Committed to your success.

We started Wireframe to serve founders solving some of the world's most important challenges. Over the years as investors & operators, we've built networks and domain expertise across themes we care deeply about. And we've been fortunate to work closely with founders from inception to success. As 1st check investors, we are completely aligned with you from the start.
‍

View openings
Our Community.

Climb together.

We're building a community where founders can share hard-earned lessons with their peers and pay it forward to the next generation when they succeed.

Highlights from our community.

Read about the latest news, interviews, and events happening across our community.
View all
Oct 2, 2024
—
Wireframe

NYC Climate Week 2024

- key learnings from our panel on how climate founders can build successful corporate partnerships
Blog
Sep 17, 2024
—
Wireframe

Our 2024 Impact Report

highlights the incredible work our portfolio companies are doing to improve the health of people & planet
News
May 21, 2024
—
Wireframe

Cocoon Carbon

is on a mission to remove millions of tonnes of CO2 and waste from heavy industry each year
Why we invested
Apr 25, 2024
—
Regeneron

Mammoth Bio

announces a milestone $100M+ partnership with Regeneron to develop in-vivo CRISPR-based gene editing therapies
News
Apr 20, 2023
—
BusinessWire

Enveda Biosciences

announces oversubscribed financing, bringing total Series B round to US$119 Million
News
Apr 7, 2022
—
Wireframe

Wireframe

announces Wireframe II, a $77M fund to back founders on a mission to improve the health of people & planet
Blog

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© 2024 Wireframe Ventures. San Francisco, CA.