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We help founders who

harness biology to

engineer better products

.

Investing in technology for people & planet

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create scalable solutions to

climate change

.

Investing in technology for people & planet

We help founders who

deploy AI & automation to

empower us

.

Investing in technology for people & planet

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We help founders who

deliver healthcare that's

personal & proactive

.

Investing in technology for people & planet

Because they are cool

and helpful

We help founders who

transport us safely, with

zero carbon footprint

.

Investing in technology for people & planet

Because they are cool

and helpful

Our Purpose.

We invest capital, time & belief to accelerate your success.

Every startup journey is unique - there's no single playbook that works for everyone, especially in the early days. We try to meet you where you are and help you get where you dream of going. We listen with empathy, we tell you the truth and we'll dive in to contribute hands-on support whenever you need it. You should expect nothing less from any investor.

We invest in driven founders who can build pioneering companies that improve our world.

Our Focus

We partner closely with our founders from the beginning, and we're on call when they need us most.

Our Approach

Harsh was the first VC we met who immediately understood our potential, and he's been a trusted mentor to me since our seed round. His empathy & experience building companies in our space make him an ideal investor for any 1st-time founder."

Trevor Martin

Co-founder & CEO, Mammoth Biosciences

Wireframe led our seed round and they’ve been invaluable to me as a solo founder. I’ve been able to rely on Paul as a true partner. We have an open, trusted relationship that goes well beyond what most founders might expect from their investors."

Arch Rao

Founder & CEO, SPAN

Wireframe’s expertise in the EV & energy markets made them the perfect lead VC for our seed round. Paul & Harsh are great partners, striking the right balance between strategic guidance & support while giving us flexibility to execute our vision."

Muffi Ghadiali

Founder & CEO, Electriphi

Before we ever raised capital, Harsh introduced us to our lead scientific advisor & spent hours with us on a whiteboard helping to hone our thinking. The Wireframe team were great partners at GeneWEAVE and we're excited to work with them again."

Diego Rey

Co-founder & CSO, Endpoint Health

Harsh is a great partner, in both good & tough times. He’s always available to help and pushes us to a high standard. And we'll forever appreciate his clarity & conviction to go all-in on Airflow, a decision that changed the course of our company."

Ry Walker

Founder, Astronomer

Wireframe's value to MycoWorks far exceeds the size of their check. This is the second time I've worked with Paul. He's always available, responsive and thoughtful. I trust his input and contribution as a true partner in building my business."

Matt Scullin

CEO, Mycoworks

Harsh brings a lifetime of wisdom coupled with uncanny insight, empathy, and authentic conviction to his investments. He is single-handedly the 'accelerator' you wished existed. He'll be the first person I call when I start my next company."

Viswa Colluru

Founder & CEO, Enveda Biosciences

Paul led our seed round and has been with me for the 7+ years since, through all of the highs and lows. There's no better partner I can imagine. Many investors say they are founder first - Paul's the real deal."

Andy Ruben

Founder & CEO, Trove

Wireframe was among the first funds to believe in us, and Paul and Harsh have been the most reliable, empathetic partners ever since. Whether supporting & advising us day-to-day or navigating a global crisis, I knew I could always lean on them."

Rema Matevosyan

Co-founder & CEO, Near Space Labs

I've worked with Harsh over 13 years as an investor in 2 of my companies. I’ve relied on his honesty and perspective on company-building time & time again. Having met hundreds of investors, he is easily in my top 5 of all time."

Tim Enwall

CEO, Misty Robotics

Our Portfolio.

View all

Our founders are on a mission to build a better future.

Product.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

People.

Purpose.

Product.

People.

Product.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

Product.

People.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

People.

Product.

Purpose.

Product.

People.

Bioscience

Permanent cures through in-vivo CRISPR-based precision editing

Mammoth Biosciences

Seed

—

January 2018

Discovering & commercializing novel CRISPR systems that enable new possibilities for expanding biology

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Energy

Maximize the profitability of energy storage projects

Tyba

Pre-seed

—

October 2022

Operate revenue-maximizing energy projects, at scale

View site →

Energy

Enabling electrification for all

SPAN.io

Seed

—

December 2018

SPAN reinvented the 100-year-old electrical panel with smarter controls for smarter savings.

View site →

Enterprise

Empowering organizations to solve their most challenging problems

Palantir

Series A

—

October 2005

Software empowering organizations with the insights they need to solve complex, mission-critical problems (NYSE: PLTR)

View site →

Bioscience

Pushing the boundaries of biomanufacturing

Caladan Bio

Seed

—

February 2024

Next-generation benchtop bioreactors for synthetic biology

View site →

Bioscience

AI-enabled discovery of differentiated medicines, at record pace

Enveda

Pre-seed

—

September 2019

Learning from life’s chemistry to create better medicines faster

View site →

Energy

Laser fusion without limits

Xcimer Energy

Seed

—

October 2022

Making nuclear fusion power a reality within a decade by building the world’s highest-energy laser system

View site →

Energy

Fleet management & energy optimization for EV fleets

Electriphi

Seed

—

December 2019

Fleet management & energy optimization software for electric vehicle fleets (acq. by Ford, NYSE: F)

View site →

Energy

Simplifying renewable energy procurement for any corporation

LevelTen Energy

Series A

—

September 2017

The industry's leading platform for corporate energy buyers to find the right renewable energy solutions

View site →

Our Team.

Meet the team

Meet our founders.

Harsh Patel

Co-Founder
Managing Director

Paul Straub

Co-Founder
Managing Director

Committed to your success.

We started Wireframe to serve founders solving some of the world's most important challenges. Over the years as investors & operators, we've built networks and domain expertise across themes we care deeply about. And we've been fortunate to work closely with founders from inception to success. As 1st check investors, we are completely aligned with you from the start.
‍

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Our Community.

Climb together.

We're building a community where founders can share hard-earned lessons with their peers and pay it forward to the next generation when they succeed.

Highlights from our community.

Read about the latest news, interviews, and events happening across our community.

View all

Apr 21, 2026

—

Wireframe

SF Climate Week 2026

- exploring why the biggest gap in AI's power race may be the capacity we're already sitting on

Blog

Mar 13, 2026

—

Semafor

Great Sky

is pioneering a new type of AI hardware enabling intelligence at the boundaries of physics

News

Sep 4, 2025

—

Fierce Biotech

Enveda Biosciences

achieves unicorn status, announces oversubscribed $150M Series D and begins enrolling patients

News

May 21, 2024

—

Wireframe

Cocoon Carbon

is on a mission to remove millions of tonnes of CO2 and waste from heavy industry each year

Why we invested

Apr 25, 2024

—

Regeneron

Mammoth Bio

announces a milestone $100M+ partnership with Regeneron to develop in-vivo CRISPR-based gene editing therapies

News

Apr 7, 2022

—

Wireframe

announces Wireframe II, a $77M fund to back founders on a mission to improve the health of people & planet

Blog

We help founders build

a healthier & more sustainable future.

Wireframe Ventures

Cocoon

March 18, 2026

—

Axios

Great Sky

March 13, 2026

—

Semafor

2025 Climate Investor Survey

September 23, 2025

—

Wireframe

Enveda Biosciences

September 4, 2025

—

Fierce Biotech

Our 2024 Impact Report

September 17, 2024

—

Wireframe

LevelTen Energy

July 16, 2024

—

MSN

Xcimer Energy

June 4, 2024

—

Axios

Mammoth Bio

April 25, 2024

—

Regeneron

CNBC

March 25, 2024

—

CNBC

Xcimer Energy

May 31, 2023

—

US DOE

We help founders who

harness biology to

engineer better products

.

Investing in technology for people & planet

We help founders who

create scalable solutions to

climate change

.

Investing in technology for people & planet

We help founders who

deploy AI & automation to

empower us

.

Investing in technology for people & planet

We help founders who

deliver healthcare that's

personal & proactive

.

Investing in technology for people & planet

We help founders who

transport us safely, with

zero carbon footprint

.

Investing in technology for people & planet

We invest capital, time & belief to accelerate your success.

Harsh was the first VC we met who immediately understood our potential, and he's been a trusted mentor to me since our seed round. His empathy & experience building companies in our space make him an ideal investor for any 1st-time founder."

Trevor Martin

Wireframe led our seed round and they’ve been invaluable to me as a solo founder. I’ve been able to rely on Paul as a true partner. We have an open, trusted relationship that goes well beyond what most founders might expect from their investors."

Arch Rao

Wireframe’s expertise in the EV & energy markets made them the perfect lead VC for our seed round. Paul & Harsh are great partners, striking the right balance between strategic guidance & support while giving us flexibility to execute our vision."

Muffi Ghadiali

Before we ever raised capital, Harsh introduced us to our lead scientific advisor & spent hours with us on a whiteboard helping to hone our thinking. The Wireframe team were great partners at GeneWEAVE and we're excited to work with them again."

Diego Rey

Harsh is a great partner, in both good & tough times. He’s always available to help and pushes us to a high standard. And we'll forever appreciate his clarity & conviction to go all-in on Airflow, a decision that changed the course of our company."

Ry Walker

Wireframe's value to MycoWorks far exceeds the size of their check. This is the second time I've worked with Paul. He's always available, responsive and thoughtful. I trust his input and contribution as a true partner in building my business."